Irritable Bowel Syndrome Relief

FDA announces discontinued marketing of Zelnorm for safety reasons.

zelnrom_pr_us_727_final_2007.pdf

This Recent Editorial in the BMJ (June 30) looked at Lactose intolerance, that I thought would be beneficial to us all.

Lactose intolerance Is common and can be diagnosed clinically and treated with simple dietary measures ^.

Lactose intolerance occurs in about 25% of people in Europe; 50-80% of people of Hispanic origin, people from south India, black people, and Ashkenazi Jews; and almost 100% of people in Asia and American Indians.¹ Lactose is a disaccharide sugar that is found exclusively in mammalian milk and is digested by the enzyme lactase in the mucosal brush border of the intestine. Reduced intestinal lactase results in malabsorption of lactose. The unabsorbed lactose is metabolised by colonic bacteria to produce gas and short chain fatty acids, causing the clinical syndrome of abdominal cramps, bloating, diarrhoea, and flatulence. Lactose malabsorption does not always cause lactose intolerance; symptoms depend on the amount and rate of lactose reaching the colon, and the amount and type of colonic flora. 

Source: BMJ 2007:334:1331-1332

Shinjini Bhatnagar, pediatric gastroenterologist and senior research scientist¹, Rakesh Aggarwal, professor²  Comments to: shinjini.bhatnagar@gmail.com